Literature summary extracted from

Nakajima, M.; Kumada, K.; Hatakeyama, K.; Noda, T.; Peters, J.M.; Hirota, T.
The complete removal of cohesin from chromosome arms depends on separase (2007), J. Cell Sci., 120, 4188-4196.

Application

EC Number	Application	Comment	Organism
3.4.22.49	molecular biology	the results show that a fraction of arm cohesin is protected by Sgo1, which prevents cohesin from being removed by the prophase pathway, and that separase is partly activated in nocodazole-arrested cells and removes the arm cohesion protected by Sgo1	Homo sapiens

Protein Variants

EC Number	Protein Variants	Comment	Organism
3.4.22.49	additional information	in cells lacking separase or expressing noncleavable Scc1, arm cohesion is not efficiently removed during nocodazole arrest	Homo sapiens

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.4.22.49	Homo sapiens	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
3.4.22.49	HeLa cell	-	Homo sapiens	-

Synonyms

EC Number	Synonyms	Comment	Organism
3.4.22.49	separase	-	Homo sapiens

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)